KINETICS OF THE DEVELOPMENT OF THE MICROCIRCULATORY TRACT OF THE MYOCARDIAL COMPLEX (LV + IVS) IN THE PROCESS OF EARLY POSTNATAL ONTOGENESIS OF RATS WISTAR

Zagoruyko G.E. та Martsinovsky V.P. та Husakovska T.M. та Filatova V.L. та Zagoruyko Yu.V. (2022) KINETICS OF THE DEVELOPMENT OF THE MICROCIRCULATORY TRACT OF THE MYOCARDIAL COMPLEX (LV + IVS) IN THE PROCESS OF EARLY POSTNATAL ONTOGENESIS OF RATS WISTAR. Вісник проблем біології і медицини, 2022 (Вип.3): (166). с. 104-109. ISSN 2077-4214

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Анотація

Determination of the kinetics of the development of the microcirculatory bed (MCB) of the mammalian myocardium remains an urgent problem of ontogenesis. The work aimed to study the regularities of the volume ratios of the capillary (cap) and arteriolo-venular (a+v) components in the process of postnatal development of the myocardial MCB in the complex "left ventricle + interventricular membrane" (LV+LV) of the heart of Wistar rats. Electronmicroscopic, optical and morphometric analysis of the ultrastructures of the MCB of the myocardium of rats from birth (d/b) to 45 days was carried out. The following morphometric parameters were determined: 1- relative volumes (%): Vvmcb, Vvcap, Vv(а+v) = (Vvmcb–Vvcap); 2 – absolute volumes (μm3): Vmcb, Vcap, V(a+v) = (Vmcb–Vcap); 3 – average daily growth rate (μm3/day): vcap/day; v(a+v)/day. It was established that after the birth of rats, the morphological processes of intensive growth of the volumes of the components of the blood microcirculatory channel occur in the myocardium (LV+IVS). In newborns and 5-day-old rat pups, numerous blood microvessels were found, the endotheliocytes of which were in the process of proliferation and differentiation. The obtained results of the conducted morphometric analysis of myocardial negatives indicated that on the 10th day after the birth of the animals, the maximum average daily growth rate of the volume of the capillary component (vcap) was determined in the MCB of the myocardium, and on the 25th day – the maximum average daily growth rate of the arteriole volume -venular component- v(a+v). In the myocardium of newborn rats, the ratio of volumes (a+v)/cap was equal to 1 : 44. At t → 45 days, there was a significant increase in the ratio of volumes v(a+v)/vcap to 1 : 3.1 as a result of absolute growth volume of microvessels (a + v). In the process of postnatal angiogenesis, the source of the formation of arterioles and venules in the blood-carrying MCB of the myocardium (LV+IVS) is the existing capillaries.

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